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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Microcell-mediated chromosome transfer ： ウィキペディア英語版 Microcell-mediated chromosome transfer Microcell Mediated Chromosome Transfer (or MMCT) is a technique used in cell biology and genetics to transfer a chromosome from a defined donor cell line into a recipient cell line. MMCT has been in use since the 1970s and has contributed to a multitude of discoveries including tumor, metastasis and telomerase suppressor genes as well as information about epigenetics, x-inactivation, mitochondrial function and aneuploidy.〔Mamm Genome. 2003 Sep;14(9):583-92. Microcell-mediated chromosome transfer (MMCT): small cells with huge potential. Doherty AM, Fisher EM.〕〔PLoS One. 2007 Feb 7;2(2):e199. Artificially introduced aneuploid chromosomes assume a conserved position in colon cancer cells. Sengupta K. et al.〕 MMCT follows the basic procedure where donor cells are induced to multinucleate their chromosomes. These nuclei are then forced through the cell membrane to create microcells, which can be fused to a recipient cell line.〔Mamm Genome. 2003 Sep;14(9):583-92. Microcell-mediated chromosome transfer (MMCT): small cells with huge potential. Doherty AM, Fisher EM.〕 ==History== MMCT was first developed in 1974 by T Ege, NR Ringertz and G Veomett by synthesizing the techniques used at the time to induce multinucleation in cells, nuclear removal and cell-cell fusions. The next major step in MMCT came during the 1980s when new transfection techniques were utilized to introduce selectable markers onto chromosomes thus making it possible to select for the introduction of specific chromosomes and more easily create defined hybrids.〔Mamm Genome. 2003 Sep;14(9):583-92. Microcell-mediated chromosome transfer (MMCT): small cells with huge potential. Doherty AM, Fisher EM.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Microcell-mediated chromosome transfer」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.